Project information
Development of diagnostics and treatment of serious heart and vascular diseases using genomic and proteomic approaches
(EPICARD)
- Project Identification
- 2B08060
- Project Period
- 3/2008 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Health and quality of life
- MU Faculty or unit
- Central European Institute of Technology
- Keywords
- Cardiovascular disorders, familial hypercholesterolemia, LDL receptor, cholesterol, aortic valve calcification, NOTCH1, DNA microarray, chromatin immunoprecipitation, real-time PCR, epigenetics, posttranslational modifications, mass spectrometry
- Cooperating Organization
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Centre for Cardiovascular and Transtplantation Surgary
- Responsible person prof. MUDr. Tomáš Freiberger, Ph.D.
- Responsible person doc. RNDr. Lenka Fajkusová, CSc.
The aim of the project is to introduce novel molecular-genetic, genomic and proteomic approaches in diagnostics of serious heart and vascular diseases.
Publications
Total number of publications: 19
2012
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A combined approach for the study of histone deacetylase inhibitors
Molecular BioSystems, year: 2012, volume: 8, edition: 11, DOI
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The logarithm of the triglyceride/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia
Clinical Biochemistry, year: 2012, volume: 45, edition: 1-2
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The molecular basis of familial hypercholesterolemia in the Czech Republic: Spectrum of LDLR mutations and genotype-phenotype correlations
Atherosclerosis, year: 2012, volume: 223, edition: 2, DOI
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Value of PCR in surgically treated patients with staphylococcal infective endocarditis: a 4-year retrospective study
European Journal of Clinical Microbiology & Infectious Diseases, year: 2012, volume: 31, edition: 6, DOI
2011
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An APEX-based genotyping microarray for the screening of 168 mutations associated with familial hypercholesterolemia
Atherosclerosis, year: 2011, volume: 216, edition: 1, DOI
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An APEX-based genotyping microarray for the screening of mutations in the LDLR gene
Year: 2011, type: Conference abstract
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Mass Spectrometry Characterization of Plant Phosphoproteins
CURRENT PROTEIN & PEPTIDE SCIENCE, year: 2011, volume: 12, edition: 2
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Optimization of mass spectral features in MALDI-TOF MS profiling of Acinetobacter species
Systematic and Applied Microbiology, year: 2011, volume: 34, edition: 1, DOI
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Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population
Clinica Chimica Acta, year: 2011, volume: 412, edition: 11-12, DOI
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Spectrum of CLCN1 and SCN4A mutations in Czech patients with non-dystrophic myotonias.
Year: 2011, type: Conference abstract