Project information
Calixarenes based glycodrugs - design, structure, antitumor and antiviral activity

Information

This project doesn't include Faculty of Economics and Administration. It includes Faculty of Science. Official project website can be found on muni.cz.
Project Identification
IAA400200503
Project Period
1/2005 - 12/2009
Investor / Pogramme / Project type
Academy of Sciences of the Czech Republic
MU Faculty or unit
Faculty of Science
Keywords
saccharides; glycosaminoacids, saccharide recognition, glycomimetics, calix[n]arenes

New water soluble ligands will be designed. The calix[n]arene scaffold in different (semi)rigid conformations, and saccharides, glycopeptides, glykosaminoacids and glycodendrons will be used as biomolecules. Computation methods (mol. dynamics) will support rational design. Synthetic methods, supramolecular chemistry - (weak interactions in complexes) and enzymatic synthesis will be used. Ligands will be tested as follows: 1. Qualitative and quantitative study of interactions of ligands (in water) attached to scaffold as a function of their spatial orientation(s). No data of this kind are available. 2. Complexation towards external guests; co-operative binding by several units with respect to their spatial orientation. Complexes of carboxylates (sialic acids) and nitric oxides donors (carbohydrate-based) will be studied. 3. Biological activity of all compounds and complexes will be screened using e.g.: activation protein NKR-P1 of the NK-cells; pertussis toxin; N-acetylhexosaminidases.

Publications

Total number of publications: 5


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