Project information
Proteiny HMGB: funkce v biologii telomer a lidských embryonálních kmenových buněk
- Project Identification
- GAP305/12/2475
- Project Period
- 1/2012 - 12/2015
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
- Cooperating Organization
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Institute of Biophysics
Studovat vliv cílené deregulace exprese chromozomálních proteinů HMGB na aktivitu telomerázy, strukturu a funkci telomer, genomovou stabilitu a pluripotenci/diferenciaci lidských embryonálních kmenových buněk.
Publications
Total number of publications: 4
2017
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Properties of Human Embryonic Stem Cells and Their Differentiated Derivatives Depend on Nonhistone DNA-Binding HMGB1 and HMGB2 Proteins
Stem Cells and Development, year: 2017, volume: 26, edition: 5, DOI
2015
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Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein
Plos one, year: 2015, volume: 10, edition: 9, DOI
2014
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Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1
Plos one, year: 2014, volume: 9, edition: 2, DOI
2012
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HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction
Chromosoma, year: 2012, volume: 121, edition: 4, DOI