MicroRNAs and Genetic Polymorphisms in Cancer

Investor logo

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

SLABÝ Ondřej

Year of publication 2012
Type Chapter of a book
MU Faculty or unit

Central European Institute of Technology

Citation
Description Single nucleotide polymorphisms (SNPs) may occur at the level of miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or the mature miRNA sequence. Such SNPs may be functional in the biogenesis and action of the mature miRNA. SNPs located to predicted miRNA target sites within 3' UTR of mRNAs have the potential to affect the efficiency of miRNA binding on its target site, create or destroy binding sites. Resulting gene deregulation can involve changes in phenotype and be eventually critical not only for the susceptibility and the onset of cancer, but also for its prognosis and therapy response prediction.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.