Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: Possible implications

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Authors	KŘEN Leoš FABIAN Pavel SLABÝ Ondřej JANÍKOVÁ Andrea SOUČEK Ondřej ŠTĚRBA Jaroslav KŘENOVÁ Zdenka MICHÁLEK Jaroslav KRÁL Zdeněk
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Pathology Research and Practice
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.ncbi.nlm.nih.gov/pubmed/22177730
Doi	http://dx.doi.org/10.1016/j.prp.2011.11.004
Field	Oncology and hematology
Keywords	HLA-E; Hodgkin lymphoma; Microenvironment; Clinical stage
Description	Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or backround microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic cells with respect to the presence of these molecule deserve further studies.
Related projects:	CEITEC - Central European Institute of Technology