Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients

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Authors

SLABÝ Ondřej RÉDOVÁ Martina POPRACH Alexandr NEKVINDOVÁ Jana ILIEV Robert RADOVÁ Lenka LAKOMÝ Radek SVOBODA Marek VYZULA Rostislav

Year of publication 2012
Type Article in Periodical
Magazine / Source Genes Chromosomes & Cancer
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://onlinelibrary.wiley.com/doi/10.1002/gcc.21957/pdf
Doi http://dx.doi.org/10.1002/gcc.21957
Field Oncology and hematology
Keywords microRNA; renal cell carcinoma; relaps; nephrectomy
Description Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney. One of the important unmet medical needs in RCC is prognostic biomarker enabling identification of patients at high risk of relapse after nephrectomy. MicroRNAs (miRNAs) constitute a robust regulatory network with posttranscriptional regulatory efficiency for almost one-half of human coding genes, including oncogenes and tumor suppressors.
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