Identification and functional screening of microRNAs highly deregulated in colorectal cancer

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Authors	FALTEJSKOVÁ Petra SVOBODA Marek ŠRŮTOVÁ Klára MLČOCHOVÁ Jitka BEŠŠE Andrej NEKVINDOVÁ Jana RADOVÁ Lenka FABIAN Pavel SLABÁ Kateřina KISS Igor VYZULA Rostislav SLABÝ Ondřej
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Journal of Cellular and Molecular Medicine
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01579.x/pdf http://www.ncbi.nlm.nih.gov/pubmed/22469014
Doi	http://dx.doi.org/10.1111/j.1582-4934.2012.01579.x
Field	Oncology and hematology
Keywords	apoptosis; colorectal cancer; expression profilin; microRNA; migration
Description	The aim of this study was to determine an expression profile of 667 miRNAs in CRC patients and paired non-tumoral tissues. We have identified 42 differentially expressed miRNAs and we have chosen 5 of them for further validation on an independent cohort of 125 CRC patients and in vitro analyses. Our results indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumor suppressors, whereas miR-135b functions as an oncogene and all these miRNAs significantly contribute to the CRC pathogenesis.
Related projects:	CEITEC - Central European Institute of Technology