Novel Multicomponent Domino Approach to 2,5-Bifunctionalized Five-Membered Cyclic Nitrones
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Synthesis |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1055/s-0031-1289726 |
| Field | Organic chemistry |
| Keywords | allenes; alcohols; aldehydes; domino reactions; multicomponent reactrions; nitrones |
| Description | Multicomponent reaction of 2,2-dimethylpenta-3,4-dienal oxime was studied. Optimum reaction conditions leading to a new family of 5-membered cyclic nitrones were found. This reaction offers direct access to target structures in a single synthetic step that involves introduction of various functional groups at positions 2 and 5 of the nitrone moiety. The reaction scope and limitations were evaluated. All products were isolated and fully characterized. |
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