Možnosti vagové stimulace v terapii bolestí hlavy - patofyziologický podklad a klinická data. Přehledový článek
| Title in English | The possibilities of vagus nerve stimulation in the treatment of headache - pathophysiological fundamentals and clinical data. An overview |
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| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Bolest |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.tigis.cz/images/stories/Bolest/2011/4_2011/05_novak_Z.pdf |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | vagus nerve stimulation; headache; migraine; cluster headache |
| Description | The extensive involvement of central nervous system structures during left vagus nerve stimulation permits considerations about potential use of vagus nerve stimulation in other functional diseases than pharmacoresistant epilepsy and treatment resistant depression. The use of vagus nerve stimulation in limited group of patients suffering from essential tremor, cognitive problems in Alzheimer disease, anxiety problems and last but not least headaches. The use of vagus nerve stimulation in patients with headache refractory to treatment is also supported by the proved effect of vagus nerve stimulation on pain perception in depressed adults and epileptic patients with chronic headache. Central inhibitory mechanisms are predominantly accepted as the mechanisms of antinociceptive effects of vagus nerve stimulation than the peripheral influence of pain perception. The most extensive literature data are available on the use of vagus nerve stimulation in the treatment of patients suffering from cluster headache and migraine, case reports of patients with chronic tension cefalea and low back pain and chronic depression were published. It is also possible to compare the results of vagus nerve stimulation and deep brain stimulation of posterior hypothalamus. Although results in less extensive group of patients and case reports of vagus nerve stimulation in intractable headache are available clinical results are promising especially when considering the fact that vagus nerve stimulation was indicated when routine treatment methods failed. |
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