Human nucleosomes: special role of CG dinucleotides and Alu-nucleosomes

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Authors	BETTECKEN Thomas FRENKEL Zakharia M. TRIFONOV Eduard
Year of publication	2011
Type	Article in Periodical
Magazine / Source	BMC Genomics
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.biomedcentral.com/1471-2164/12/273
Doi	http://dx.doi.org/10.1186/1471-2164-12-273
Field	Genetics and molecular biology
Keywords	NUCLEOTIDE-SEQUENCE; DNA METHYLATION; CHROMATIN DNA; PATTERN; ELEGANS; CORE; RESOLUTION; POSITION; ELEMENTS; GENOME
Description	The periodical occurrence of dinucleotides with a period of 10.4 bases now is undeniably a hallmark of nucleosome positioning. Considering the exceptional role CG dinucleotides play in the nucleosome positioning, we hypothesize that Alu-nucleosomes, especially, those that form tightly positioned runs, could serve as "anchors" in organizing the chromatin in human cells.
Related projects:	Molecular basis of cell and tissue regulations CHROMPLANT