Role of Everlasting Triplet Expansions in Protein Evolution

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	KOREN Zohar TRIFONOV Eduard
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Journal of molecular evolution.
MU Faculty or unit	Central European Institute of Technology
Citation
Doi	http://dx.doi.org/10.1007/s00239-010-9425-0
Field	Genetics and molecular biology
Keywords	Codon usage; Evolutionary play-ground; Fast adaptation; First exons; Genome inflation; Homopeptides; Selfish DNA; Tandem repeats; Triplet code; Triplet expansion disorders
Description	Analysis of occurrence of simple amino acid repeats in large ensemble of prokaryotic and eukaryotic sequences reveals that nearly all amino acids found in the repeats belong to those which have in their codon repertoires aggressively expanding triplets, all of three known pathologically expanding classes GCU (GCU, CUG, UGC, AGC, GCA, CAG), GCC (GCC, CCG, CGC, GGC, GCG, CGG), and AAG (AAG, AGA, GAA, CTT, TTC, TCT).The spontaneous expansions continued to occur all the way during evolution, leaving their footprints in the protein-coding sequences as still visible simple amino acid repeats, as preferred triplets encoding the repeats, and as preferred codons in the codon usage tables.
Related projects:	Molecular basis of cell and tissue regulations