Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing

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Authors	CRHÁK KHAITOVÁ Lucie FOJTOVÁ Miloslava KŘÍŽOVÁ Kateřina LUNEROVÁ Jana FULNEČEK Jaroslav DEPICKER Anna KOVAŘÍK Aleš
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Epigenetics
MU Faculty or unit	Central European Institute of Technology
Citation
Doi	http://dx.doi.org/10.4161/epi.6.5.15764
Field	Genetics and molecular biology
Keywords	transcriptional gene silencing; transgene epialleles; DNA methylation; small RNA
Description	It has been well established that trans-acting small RNAs guide promoter methylation leading to its inactivation and gene silencing at the transcriptional level (TGS).These features contrast with a non-methylated single copy transgenic locus that required several generations of contact with RNA silencing molecules to become imprinted in a stable epiallele.
Related projects:	Molecular basis of cell and tissue regulations