Levels of nestin protein correlate with 1q21 gain and hyperdiploidy in multiple myeloma

Šváchová,  Hana; Němec,  Pavel; Mikulášová,  Aneta; Hatlapatková,  Kristina; Grešliková,  Henrieta; Říhová,  Lucie; Hájek,  Roman

Levels of nestin protein correlate with 1q21 gain and hyperdiploidy in multiple myeloma

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Authors	ŠVÁCHOVÁ Hana NĚMEC Pavel MIKULÁŠOVÁ Aneta BERÁNKOVÁ Kristina GREŠLIKOVÁ Henrieta KOVÁŘOVÁ Lucie HÁJEK Roman
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Nestin is considered to be a suitable diagnostic and prognostic indicator of malignancy and a marker of cancer stem cells in solid tumors. The aim of this study was to correlate nestin levels with cytogenetic abnormalities in PC of MM patients. Our results indicate that high % Nes+PC or nestin levels significantly correlate with 1q21 gain, and low nestin levels correlate with HY. We suppose that nestin could associate with unfavorable prognosis but further studies are required to elucidate its clinical implication for MM
Related projects:	University Research Centre - Czech Myeloma Group Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií