Myeloid-derived suppressor cells are elevated in MGUS and MM patients
| Authors | |
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| Year of publication | 2011 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells consists myeloid progenitors and immature myeloid cells. In healthy individuals, these immature myeloid cells differentiate into granulocytes, macrophages and dendritic cells. In contrast, pathological conditions including cancers and auto-immune diseases MDSCs are expanded and impose suppressive functions on immune cells. In this study using flow cytometry we screened MDSCs in 78 peripheral blood (PB) and bone marrow (BM) samples with discrete clinical representations of monoclonal gammopathies (MGs) including: MGUS-(13/78), newly diagnosed MM-(31/78), relapsed MM-(16/78) and patients in remission-(18/78). For comparison 10 healthy volunteers (HVs) PB was also analyzed. Phenotype of MDSCs was characterized as CD33+CD11b+CD14-(HLA-DR)- and quantification was performed from all myeloid cells. A significant elevation was observed in the level of PB MDSCs for MG patients compared to HVs [0.44% (0.13%-5.38%)vs. 0.13% (0.02%-0.45%); P=0.0004]. Comparison of PB MDSCs between HVs and various clinical entities of MGs are summarized in Table 1. BM MDSCs showed an insignificant pattern of increase in MGUS cohort compared to MM cohort [0.52% (0.12%-1.72%) vs. 0.38% (0.07%-9.02%); P=0.60]. Correlation analysis showed a negative association in between ?2-microglobulin level and BM MDSCs (r=-0.34; P=0.002). In conclusion, these elevated MDSCs in MM patients might induce immune deregulation by their suppressive function. |
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