Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites

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Authors

ZOUNKOVÁ Radka KOVALOVÁ Lubomíra BLÁHA Luděk DOTT Wolfgang

Year of publication 2010
Type Article in Periodical
Magazine / Source Chemosphere
MU Faculty or unit

Faculty of Science

Citation
Field Environment influence on health
Keywords Cytostatics; Cytotoxic drugs; Metabolites; Ecotoxicity; Cenotoxicity; Chronic effects
Description This study reported ecotoxicity and genotoxicity of three widely used cytostatic agents (5-fluorouracil (5-FU), cytarabine (CYT) and gemcitabine (GemC) and their major human metabolites, i.e. alpha-fluoro-beta-alanine (FBAL), uracil-1-beta-D-arabinofuranoside (AraU) and 2',2'-difluorodeoxyuridine (dFdU)).
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