Nucleosome Positioning by Sequence, State of the Art and Apparent Finale
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | ANGSTROM RESOLUTION; CORE PARTICLE; DNA-SEQUENCE; NUCLEOTIDE-SEQUENCE; CHROMATIN DNA; C. ELEGANS; PAIR DNA; PATTERN; GENOME; DINUCLEOTIDES |
| Description | All major suggestions about the nucleosome positioning sequence pattern(s) are overviewed. Two basic binary periodical patterns are well established: in purine/pyrimidine alphabet YRRRRRYYYYYR and in strong/weak alphabet -SWWWWWSSSSSW. Their merger in four-letter alphabet sequence coincides with first ever complete matrix of nucleosome DNA bendability derived from very large database of nucleosome DNA sequences. Its simplified linear form is CGGAAATTTCCG. Several independent ways of derivation of the same pattern are described. It appears that the pattern represents an ultimate solution of long-standing problem of nucleosome positioning, and provides simple means for nucleosome mapping on sequences with single-base resolution. |
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