Single-base Resolution Nucleosome Mapping on DNA Sequences

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Authors	GABDANK Idan BARASH Danny TRIFONOV Eduard
Year of publication	2010
Type	Article in Periodical
Magazine / Source	JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Chromatin code; DNA hendability; Nucleosome DNA; Nucleosome positioning; Nucleosome structure
Description	Nucleosome DNA bendahility pattern extracted from large nucleosome DNA database of C. elegans is used for construction of full length (116 dinucleotide positions) nucleosome DNA bendahility matrix. The matrix can he used for sequence-directed mapping of the nucleosomes on the sequences. Several alternative positions for a given nucleosome are typically predicted. separated by multiples of nucleosome DNA period. The corresponding computer program is successfully tested on best known experimental examples of accurately positioned nucleosomes. The uncertainty of the computational mapping is +/- 1 base. The procedure is placed on publicly accessible server and can he applied to any DNA sequence of interest.
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