125I-labelled iodothyronines: useful tools for studies of effects of an antidepressant drug fluoxetine in the rat

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Authors

PAVELKA Stanislav

Year of publication 2010
Type Article in Periodical
Magazine / Source Journal of Radioanalytical and Nuclear Chemistry
MU Faculty or unit

Faculty of Science

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Antidepressant drug; radiometric enzyme assay; thyroid hormone
Description We followed the effects of an antidepressant drug fluoxetine (Fluox), administered sub-chronically to Wistar rats by itself, or in combination with 3,3',5-triiodothyronine. In studies of the interaction of Fluox with the metabolism of thyroid hormones, we applied adapted radiometric enzyme assays for iodothyronine sulfotransferases and uridine 5'-diphospho-glucuronyltransferase, as well as our newly developed radiometric assays for iodothyronine deiodinases of types 1, 2 and 3, using 125I-labelled iodothyronines of high specific radioactivity as substrates.
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