Biomarker discovery in low grade breast cancer: A proteomics based approach

Bouchal,  Pavel; Dvořáková,  Monika; Roumeliotis, Theodoros; Hernychová,  Lenka; Hrstka,  Roman; Garbis, Spiros D.; Nenutil,  Rudolf; Vojtěšek,  Bořivoj

Biomarker discovery in low grade breast cancer: A proteomics based approach

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Authors	BOUCHAL Pavel MUDROCHOVÁ Monika ROUMELIOTIS Theodoros HERNYCHOVÁ Lenka HRSTKA Roman GARBIS Spiros D. NENUTIL Rudolf VOJTĚŠEK Bořivoj
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Traditional prognostic markers of low-grade breast cancer are currently not sufficient for precise risk-group discrimination. Our effort was thus focused on biomarker discovery in this tumor group. Three proteomics approaches were involved in complex protein analysis of tissue lysates: SELDI-TOF MS, iTRAQ-2DLC-MS/MS and 2-D SDS-PAGE. Differentially expressed proteins belong to several functional groups related to breast cancer biology and are presented and discussed on the poster.
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