Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2

• Authors: WITTE Florian; BERNATÍK Ondřej; KIRCHNER Katharina; MAŠEK Jan; MAHL Annika; KREJČÍ Pavel; MUNDLOS Stefan; SCHAMBONY Alexandra; BRYJA Vítězslav; STRICKER Sigmar
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: FASEB JOURNAL
• MU Faculty or unit: Faculty of Science
• Doi: http://dx.doi.org/10.1096/fj.09-150615
• Field: Genetics and molecular biology
• Keywords: Wnt/beta-catenin signaling; casein kinase; Ror2
• Description: Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.

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