Vang-like protein 2 and Rac 1 interact to regulate adherens junctions

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Authors

LINDQVIST Maria HORN Zachi BRYJA Vítězslav SCHULTE Gunnar PAPACHRISTOU Panagiotis AJIMA Rieko DYBERG Cecilia ARENAS Ernest YAMAGUCHI Terry P LAGERCRANTZ Hugo RINGSTEDT Thomas

Year of publication 2010
Type Article in Periodical
Magazine / Source JOURNAL OF CELL SCIENCE
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Cell adhesion; Neurulation; PCP; Wnt
Description The Wnt Planar Cell Polarity (PCP) pathway signals through small Rho-like GTPases to regulate the cytoskeleton. Here we investigate the function of the mammalian PCP protein Vangl2. We propose that Vangl2 affects cell adhesion and the cytoskeleton by recruiting Rac1 .
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