Growth Differentiation Factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts
| Authors | |
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| Year of publication | 2009 |
| Type | Article in Proceedings |
| Conference | the FEBS Journal, 256, Suppl. 1 |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | GDF-15; osteoclats; prostate cancer |
| Description | Prostate cancer is a common disease in industrial countries. Prostate tumors preferentially disseminate to bones and induce significant rearrangement of the bone architecture. T The aim of this study is to characterize effects of growth differentiation factor-15 (GDF-15) secreted by prostate cancer cells on the osteoclastic differentiation pathway. This study documents that GDF-15 both as purified substance and as unpurified product secreted by prostate cancer cells strongly interferes with differentiation of osteoclasts by inhibiting expression and activity of NFkB and c-Fos. |
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