Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions

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Authors	NOVÁK Jiří JÁLOVÁ Veronika GIESY JP HILSCHEROVÁ Klára
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Environment International
MU Faculty or unit	Faculty of Science
Citation
Field	Air pollution and control
Keywords	air; endocrine disruption; dioxin-like toxicity; antiestrogenic; antiandrogenic
Description	Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions. Traditionally, contamination of air has been evaluated primarily by chemical analyses of indicator contaminants and these studies have focused mainly on compounds associated with particulates. Some reports have shown that air contaminants can produce specific biological effects such as toxicity mediated by the aryl hydrocarbon receptor (AhR) or modulation of the endocrine system. This study assessed the dioxin-like toxicity, anti/estrogenicity, anti/androgenicity and anti/retinoic activity of both the particulate and gas phase fractions of air in two regions with different types of pollution sources and a background locality situated in an agricultural area of Central Europe.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.