Phenotype of Plasma Cells in Multiple Myeloma
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Multicolor flow cytometry is widely used in analysis of haematologic malignancies, but not so often in monoclonal gammopathies. Markers associated with malignat plasma cells (PCs) are known, but only limited information about their relation to prognosis is available. Detailed analysis of PCs phenotype in multiple myeloma (MM) patients can bring new information about prognostic impact of some markers. In this work expression of CD19, CD20, CD27, CD28, CD56 and CD117 was analysed on CD38+CD138+ PCs from bone marrow of 69 newly diagnosed MM patients. Our results confirmed that in these patients a majority of plasma cells are abnormal CD19-CD56+ PC. PCs of 40 patients expressed CD20, CD27, CD28 and CD117 in 10% (4/40); 50% (20/40); 45% (18/40) and 47.5% (19/40) of cases, respectively. Further follow-up of patients would confirm some of mentioned marker as a parameter related to their prognosis. These markers can be also used in monitoring of minimal residual disease. |
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