CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Biological Chemistry |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Wnt signalling; CXXC5; neural stem cells |
| Description | In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells, we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly up-regulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate Dishevelled and attenuate Wnt signalling. We conclude that CXXC5 is a BMP4-induced inhibitor of Wnt signaling in neural progenitors. |
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