Metody používané v hodnocení angiogeneze a jejich význam u mnohočetného myelomu.

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Title in English	METHODS USED FOR EVALUATION OF ANGIOGENESIS AND THEIR SIGNIFICANCY FOR MULTIPLE MYELOMA
Authors	POUR Luděk ŠVÁCHOVÁ Hana SLANÝ Michal HÁJEK Roman
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Klinická onkologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	angiogenesis;multiple myeloma
Description	It is confi rmed that angiogenesis is increased not only in solid tumor but in hemtological malignancies too. Angiogenesis is complicated procedure, where lot of factor s are infl uenced. Probably, angiogenesis plays two roles in myeloma developement new born vessels 1st. provide adequate nutrition of tumor cells, 2nd. Angiogenic cytokines stimulace migration and growth of myeloma cells. Measurement of angiogenesis degree is possible according to MVD and by measurement of cytokine levels developed in angiogenesis.
Related projects:	University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies