Metody používané v hodnocení angiogeneze a jejich význam u mnohočetného myelomu.

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Title in English METHODS USED FOR EVALUATION OF ANGIOGENESIS AND THEIR SIGNIFICANCY FOR MULTIPLE MYELOMA
Authors

POUR Luděk ŠVÁCHOVÁ Hana SLANÝ Michal HÁJEK Roman

Year of publication 2008
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords angiogenesis;multiple myeloma
Description It is confi rmed that angiogenesis is increased not only in solid tumor but in hemtological malignancies too. Angiogenesis is complicated procedure, where lot of factor s are infl uenced. Probably, angiogenesis plays two roles in myeloma developement new born vessels 1st. provide adequate nutrition of tumor cells, 2nd. Angiogenic cytokines stimulace migration and growth of myeloma cells. Measurement of angiogenesis degree is possible according to MVD and by measurement of cytokine levels developed in angiogenesis.
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