Význam cytogenetických změn u relabujících pacientů s mnohočetným myelomem léčených novými typy léků

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Title in English	The Impact of Cytogenetic abnormalities in relapsing multiple myeloma patients treated by new types of drugs
Authors	ZAORALOVÁ Romana KUGLÍK Petr VRANOVÁ Vladimíra OLTOVÁ Alexandra POUR Luděk KŘIVANOVÁ Andrea KREJČÍ Marta ADAM Zdeněk HÁJEK Roman
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Klinická onkologie, Supplementum
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	Multiple myeloma; cytogenetics; FISH; Velcade; Thalidomid
Description	In this paper we show an example of use the detection of chromosomal abnormalities (deletion 13q14, translocation t(4;14), deletion 17q13 and gain 1q21) using modified fluorescence in situ hybridization (FISH) and following searching for the impact of chromosomal abnormalities to succesful treatment of multiple myeloma patients.
Related projects:	Molecular basis of cell and tissue regulations University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies