Význam sledování exprese nádorových testikulárních antigenů u mnohočetného myelomu a monoklonálních gamapatií

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Title in English	Impact of cancer/testis antigens /(CTA) expression in multiple myeloma (MM) and monoclonal gammapathy (MGUS)
Authors	NEČASOVÁ Jana KADLECOVÁ Jitka KADLECOVÁ Jitka SPĚŠNÁ Renata SPĚŠNÁ Renata PENKA Miroslav PENKA Miroslav HÁJEK Roman HÁJEK Roman
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Klinická onkologie Supplement 2008
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	multiple myeloma; monoclonal gammapathy; cancer/testis antigen
Description	The human MAGE gene family which is a group of "cancer/testis antigens" (CTA) encodes products that can be recognized by autologous cytotoxic T cells. CT antigens are expressed in several malignant tumors, but not in normal tissues except for testis and placenta. CT antigens are frequently expressed in MM and represents promising candidates for cancer- specific immunotherapy in multiple myeloma. An obvious correlation between the expression of these genes and the stage of the disease has been observed. We examined the expression of MAGE-A1 and MAGE-A3 in bone marrow in a group of patiens with monoclonal gammapathy and in patients with early and advanced stage of the multiple myeloma.
Related projects:	University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies