Antibacterial C-Geranylflavonoids from Paulownia tomentosa Fruits

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Authors	ŠMEJKAL Karel CHUDÍK Stanislav KLOUČEK Pavel MAREK Radek CVAČKA Josef URBANOVÁ Marie JULÍNEK Ondřej KOKOŠKA Ladislav ŠLAPETOVÁ Tereza HOLUBOVÁ Pavla ZIMA Aleš DVORSKÁ Margita
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Journal of Natural Products
MU Faculty or unit	Faculty of Science
Citation
Web	DOI: 10.1021/np070446u
Doi	http://dx.doi.org/10.1021/np070446u
Field	Analytic chemistry
Keywords	geranylflavonoid; Paulownia tomentosa; antibacterial; NMR
Attached files	JNP08_71_706.pdf
Description	Eight C-6-geranylflavonoids (1-8) were isolated from an ethanol extract of Paulownia tomentosa fruits. Tomentodiplacone (1), 3-O-methyl-5-hydroxydiplacone (2), 3-O-methyl-5-O-methyldiplacone (3), and tomentodiplacone B (4) were obtained as new compounds, and 3-O-methyldiplacol (5) was isolated for the first time from a natural source. The structures of these new compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy, and the absolute configurations of the compounds were determined by circular dichroism. The antibacterial activities of 1-8 against seven bacteria and yeast were evaluated.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Biomolecular centre