Antibacterial C-Geranylflavonoids from Paulownia tomentosa Fruits

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Authors

ŠMEJKAL Karel CHUDÍK Stanislav KLOUČEK Pavel MAREK Radek CVAČKA Josef URBANOVÁ Marie JULÍNEK Ondřej KOKOŠKA Ladislav ŠLAPETOVÁ Tereza HOLUBOVÁ Pavla ZIMA Aleš DVORSKÁ Margita

Year of publication 2008
Type Article in Periodical
Magazine / Source Journal of Natural Products
MU Faculty or unit

Faculty of Science

Citation
Web DOI: 10.1021/np070446u
Doi http://dx.doi.org/10.1021/np070446u
Field Analytic chemistry
Keywords geranylflavonoid; Paulownia tomentosa; antibacterial; NMR
Attached files
Description Eight C-6-geranylflavonoids (1-8) were isolated from an ethanol extract of Paulownia tomentosa fruits. Tomentodiplacone (1), 3-O-methyl-5-hydroxydiplacone (2), 3-O-methyl-5-O-methyldiplacone (3), and tomentodiplacone B (4) were obtained as new compounds, and 3-O-methyldiplacol (5) was isolated for the first time from a natural source. The structures of these new compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy, and the absolute configurations of the compounds were determined by circular dichroism. The antibacterial activities of 1-8 against seven bacteria and yeast were evaluated.
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