Srovnání vybraných markerů dendritických buněk u zdravých dárců a pacientů s monoklonální gamapatií nejasného významu či mnohočetným myelomem

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Title in English	Comparison of DCs antigens in healthy volunteers and monoclonal gammopathy and/or multiple myeloma patients
Authors	KOVÁŘOVÁ Lucie MICHÁLEK Jaroslav KÝR Michal PENKA Miroslav HÁJEK Roman
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Klinická onkologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	dendritic cells; monoclonal gammopathy of undetermined significancy; multiple myeloma; flowcytometry
Description	Dendritic cells are higly specialized antigen-presenting cells, which can be used for immunotheraphy trials. Functionally normal DCs play a critical role in the activation and potentiation of tumor antigen-specific responses. Under serum free conditions there was no difference in healthy volunteers, MGUS and MM patients, but CD40L stimulation did not lead to the full maturation of DCs. Patients autologous serum had a negative influence on DCs, but it was depending not only on IL-6 level.
Related projects:	University Research Centre - Czech Myeloma Group