Retinoic acid enhances differentiation of v-myb-transformed monoblasts induced by okadaic acid

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Authors

BENEŠ Petr MACEČKOVÁ Vendula ZATLOUKALOVÁ Jiřina KOVÁŘOVÁ Lucie ŠMARDOVÁ Jana ŠMARDA Jan

Year of publication 2007
Type Article in Periodical
Magazine / Source Leukemia Research
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords v-myb; monoblast; macrophage; differentiation; okadaic acid; retinoic acid; protein phosphatase
Description Differentiation of various leukemic cells can be induced by liganded retinoic acid receptors and phosphatase inhibitors. In this study, we explored the effects of okadaic acid (OA), the phosphatase inhibitor, and retinoic acid (RA) in v-myb-transformed monoblasts BM2. OA induced differentiation of BM2 cells into macrophage-like cells. In contrast to many other leukemic cell lines, BM2 cells do not respond to RA. However, once exposed to OA and RA simultaneously, BM2 cells differentiate alone monocyte/macrophage pathway more efficiently. We conclude that RA enhances differentiation of v-myb-transformed monoblasts induced by protein phosphorylation.
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