AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?

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Authors

BITTNER Michal HILSCHEROVÁ Klára GIESY John, Paul

Year of publication 2007
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed.
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