AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?

Bittner,  Michal; Hilscherová,  Klára; Giesy, John, Paul

AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?

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Authors	BITTNER Michal HILSCHEROVÁ Klára GIESY John, Paul
Year of publication	2007
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants