Interference of N-heterocyclic PAHs with signaling of retinoids

Beníšek,  Martin; Pacherník,  Jiří; Bláha,  Luděk; Hilscherová,  Klára

Interference of N-heterocyclic PAHs with signaling of retinoids

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Authors	BENÍŠEK Martin PACHERNÍK Jiří BLÁHA Luděk HILSCHEROVÁ Klára
Year of publication	2007
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160.
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