Experimental Models of Peripheral Neuropathic Pain - An Anatomical View
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Morpholgy 2006 |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | dorsal root ganglia - neuropathic pain models |
| Description | The neuropathic pain (NP) is initiated or caused by a primary lesion or dysfunction in the nervous system. In order to identify novel therapeutics and to design compounds for clinical use, it is important to understand the underlying NP mechanisms. To explore mechanisms of the peripheral NP, several experimental models have been developed. The goal of our paper is to review models of the peripheral NP in respect of affected dorsal root ganglia (DRG) neurons. The models differ in a form and location of the peripheral nerve injury. The former includes the nerve transection related with total axonal disconnection (axotomy) and loose or tight ligations that mimic only a partial damage of the nerves. Based on the location of nerve injury, the models can be divided into two major groups. The first comprises models of the peripheral nerve injury, either total nerve transection (axotomy) or partial nerve injury (PNI). The most used approach of PNI is i/ partial ligature of the sciatic nerve, ii/ chronic constriction of the sciatic nerve, iii/ tight ligation of L5/L6 spinal nerves and iv/ spared nerve injury with several modifications. The second group of models includes an injury of both dorsal and ventral roots of the spinal nerves. All experimental models result in behavioral changes measured as thermal hyperalgesia and mechanical allodynia. From anatomical point of view, the different experimental models affect the DRG neurons of various ranges that could result in diverse mechanisms of the peripheral NP. |
| Related projects: |