Glutamatergics and addiction

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Authors

ŠULCOVÁ Alexandra JEŽOVÁ Daniela

Year of publication 2006
Type Article in Periodical
Magazine / Source Homeostasis in Health and Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords addiction; glutamte; memantine; phenytoin; mice;rats
Description The noncompetitive NMDA receptor antagonist memantine did not produce significant alteration of sensitization either to methamphetamine stimulatory effects on mouse locomotor/exploratory behaviour in the open field test or to methamphetamine inhibitory antiaggressive effects in singly-housed mice on dyadic social interactions with non-aggressive group-housed partners. Blockade of glutamate release by treatment with phenytoin (not changing locomotor behaviour in the open field test) prevented the development of compulsory wheel running - an animal model of excercise addiction in humans.
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