Simultaneous HPLC determination of markers of metabolic activity of CYP1A2 and CYP2C6

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Authors

JUŘICA Jan TOMANDL Josef ZAHRADNÍKOVÁ Lucia ZENDULKA Ondřej HADAŠOVÁ Eva

Year of publication 2006
Type Article in Proceedings
Conference Book of abstracts, Central/Eastern European CINP Regional meeting
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords determination; cytochrome; CYP2C6; CYP1A2
Description The presented method allows to determine concentration of both markers of metabolic activity of CYP1A and CYP2C (phenacetine and tolbutamide) and their metabolites paracetamol and 4-hydroxytolbutamide in rat liver perfusate, respectively. This method is suitable for modeling and description of possible pharmacological interactions on isoforms CYP1A2 and CYP2C6 in rat.
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