Gender differences in effects of MDMA, cannabinoid agonist and their combinations in mice

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Title in English	Gender differences in effectS of MDMA, cannabinoid agonist and their combinations in mice.
Authors	KUČEROVÁ Jana LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra
Year of publication	2006
Type	Article in Periodical
Magazine / Source	European Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	gender differences; behavioural sensitization; mice; ecstasy; methanandamide
Description	The outcome of the present study showed higher susceptibility of female mice to acute MDMA administration, however the behavioural sensitization development (during the repeated treatment) and expression (caused by the challenge dose given after the drug withdrawal) were confirmed only in males. The pretreatment with cannabinoid CB1 receptor agonist led to sensitization to MDMA stimulatory effects in all animals.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.