MDMA pre-treatment cross-sensitizes to methamphetamine stimulatory effects in mice

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Authors	KUČEROVÁ Jana LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra
Year of publication	2006
Type	Article in Periodical
Magazine / Source	European Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	behavioural sensitization; mice; ecstasy; methamphetamine
Description	Various psychostimulant drugs induce after their repeated administration a significant increase in behavioural responses, phenomenon known as behavioural sensitization. In our recent studies we demonstrated development of this phenomenon after repeated administration of methamphetamine (Met) and its expression following Met challenge dose after the withdrawal lasting 6 days. Furthermore, pretreatment with CB1 receptor agonist methanandamide elicited behavioural cross-sensitization to Met stimulatory effects. By analogy, we decided to test a possible cross-sensitization to Met with another widely abused substance - MDMA (ecstasy), and vice versa with Met repeated pretreatment to MDMA effects.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.