Identifikace individuálních autologních kolonů myelom-reaktivních T lymfocytů

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Title in English Identification of individual autologous clones of myeloma-reaktive T lymphocytes
Authors

DUDOVÁ Silvie HORÁK Radovan KOVÁŘOVÁ Lucie HORVÁTH Radek HÁJEK Roman MICHÁLEK Jaroslav

Year of publication 2006
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords multiple myeloma ; immunotherapy ; T cell receptor ; hypervariable region ; clonotype
Description Multiple myeloma (MM) is a hematooncologic disease caused by malignant tranformation of B-lymphocytes, their clonal proliferation and accumulation of terminal stages-plasmocytes (myeloma cells). Recently, high-dose chemotherapy with autologous hematopoietic transplantation has been considered standard treatment for patients with advanced stages of multiple myeloma. Such treatment delays replase but it is not curative and almost all patients ultimately develop recurrent disease.
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