Preparation of 1-Adamantylketones: Structure, Mechanism of Formation and Biological Activity of Potential Byproducts

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Authors	VÍCHA Robert NEČAS Marek POTÁČEK Milan
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Collection of Czechoslovak Chemical Communications
MU Faculty or unit	Faculty of Science
Citation
Field	Organic chemistry
Keywords	Collect. Czech. Chem. Commun. 2006; 71(5); 709-722.
Description	Reactions between adamantane-1-carbonyl chloride and several Grignard reagents as well as interactions with solvents have been examined. Some new and unexpected adamantane derivatives were isolated, fully characterized and their biological activity determined. In particular, an unexpected isochromanone 16 was formed in an SEAr process where a stable hydrocarbon was the leaving group.
Related projects:	Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles