Gender differences in cannabinoid and ecstasy interacting effects in mice

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Authors

KUČEROVÁ Jana NOVÁKOVÁ Jana LANDA Leoš ŠULCOVÁ Alexandra

Year of publication 2006
Type Article in Periodical
Magazine / Source Homeostasis in Health and Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Gender differences; ecstasy; open field; cannabinnoid
Description The present experiment was focused on a possible cross-sensitization to ecstasy with repeated application of cannabinoid CB1 receptor ligands with (agonist methanandamide) or without (AM 251) intrinsic activity. We also have considered possible gender differences which other authors had described in behavioural effects of ecstasy in mice. Evaluation of behavioural sensitization was based on changes of drug effects on mouse locomotor activity in the open field test measured by the device Actitrack. Both, male and female mice of the same age were used.
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