Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model

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Authors

CHRISTÉ Georges RESTIER L. CHAHINE M. CHEVALIER P. PÁSEK Michal

Year of publication 2005
Type Article in Proceedings
Conference Computers in cardiology 2005
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords cardiac cell persistent; sodium current; quantitative modelling
Description In LQT3 patients, SCN5A mutations were found that lead to a small fraction of persistent hNav1.5 current. We explored the effects of such a change on the intracellular ionic homeostasis and arrhythmogenesis in a model of guinea-pig cardiac ventricular cell.
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