Comparison of the genomes of pathogenic treponemes, Treponema pallidum ssp. pallidum, ssp. pertenue and Treponema paraluiscuniculi.

Investor logo

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

ŠMAJS David STROUHAL Michal MATĚJKOVÁ Petra NORRIS S.J. WEINSTOCK G.M.

Year of publication 2005
Type Article in Proceedings
Conference Clinical Microbiology and Infection
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords Treponema pallidum ssp. pallidum; Treponema pallidum ssp. pertenue; Treponema paraluiscuniculi
Description Objectives. Genomes of closely related treponemes, Treponema pallidum ssp. pallidum (strains Nichols and SS14) and Treponema pallidum ssp. pertenue (Gauthier, Samoan D) were compared with the genome of Treponema paraluiscuniculi using genomic techniques. T. pallidum ssp. pallidum is the causative agent of a highly invasive human disease syphilis, T. pallidum ssp. pertenue is the causative agent of yaws and T. paraluiscuniculi is not pathogenic to humans. After labelling of chromosomal DNA using random hexamers and hybridization to the DNA microarray, at least 15 T. paraluiscuniculi genes showed significantly lower signals when compared to signals of T. pallidum ssp. pallidum.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.