Kombinace antidepresiv

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Title in English Combination of antidepressants
Authors

ČEŠKOVÁ Eva

Year of publication 2005
Type Article in Periodical
Magazine / Source Remedia
MU Faculty or unit

Faculty of Medicine

Citation
Field Psychiatry, sexuology
Keywords drug resistant depression; residual symptoms; side effect; augmentation; combination of antidepressants; serotonin syndrome.
Description Therapeutical possibilities in low responsiveness to the first antidepressant are summarized. Combinations of antidepressants are discussed in detail. In clinical practise, combination of antidepressants is primarily used to overcome drug resistance and to control side effect and residual symptoms. Controlled double-blind studies are scare; the last review article onlz reported eight of these. Combinations of selective serotonin reuptake inhibitors(SSRI) or serotonin noradrenalin reuptake inhibitors (SNRI) with mirtazapine are promising in overcoming drug resistance. Combination of SSRI and bupropion is most frequently used in SSRI related sexual dysfunction management. Antidepressant combinations increase the risk of serotonin syndrome.
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