VALIDATION OF A CAPILLARY ZONE ELECTROPHORESIS METHOD FOR DETERMINATION OF RIMANTADINE HYDROCHLORIDE IN RIMANTADIN100 TABLETS AND THE METHOD APPLICATION TO DISSOLUTION TEST MONITORING

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Authors	PAZOUREK Jiří REVILLA Alma GAJDOŠOVÁ Dagmar HAVEL Josef
Year of publication	2004
Type	Article in Periodical
Magazine / Source	DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
MU Faculty or unit	Faculty of Science
Citation
Field	Analytic chemistry
Keywords	capillary zone electrophoresis
Description	A capillary zone electrophoretic method with indirect UV-detection for determination of rimantadine, an antiviral drug against influenza A, in tablets was validated. Instrumental precision, the method precision, accuracy, calibration curve linearity, selectivity, robustness and time stability of the sample and the standard were tested. The method was also applied to monitor dissolution tests of the tablets. The possibility of internal standard for improvement of method precision was discussed.
Related projects:	Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles