VALIDATION OF A CAPILLARY ZONE ELECTROPHORESIS METHOD FOR DETERMINATION OF RIMANTADINE HYDROCHLORIDE IN RIMANTADIN100 TABLETS AND THE METHOD APPLICATION TO DISSOLUTION TEST MONITORING

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Authors

PAZOUREK Jiří REVILLA Alma GAJDOŠOVÁ Dagmar HAVEL Josef

Year of publication 2004
Type Article in Periodical
Magazine / Source DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
MU Faculty or unit

Faculty of Science

Citation
Field Analytic chemistry
Keywords capillary zone electrophoresis
Description A capillary zone electrophoretic method with indirect UV-detection for determination of rimantadine, an antiviral drug against influenza A, in tablets was validated. Instrumental precision, the method precision, accuracy, calibration curve linearity, selectivity, robustness and time stability of the sample and the standard were tested. The method was also applied to monitor dissolution tests of the tablets. The possibility of internal standard for improvement of method precision was discussed.
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