Interspecies comparison of sensitization to methamphetamine effects on locomotion in mice and rats.

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Authors	LANDA Leoš ŠLAIS Karel HANESOVÁ Mariana ŠULCOVÁ Alexandra
Year of publication	2005
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	behavioural sensitization; methamphetamine; rat; mouse
Description	Repeated exposure to drugs of abuse results in a typical progressive enhancement of their behavioural effects, namely stimulation of locomotion and occurrence of stereotypies. This phenomenon is termed behavioural sensitization. In our previous study we confirmed sensitization to methamphetamine (Met) stimulatory effects on locomotion in mice using our original dosage regimen. To investigate possible interspecies differences in susceptibility to drug sensitization we applied the same experimental design to rats.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems