Prognóza nádorů hlavy a krku se zaměřením na nádorový supresor p53
| Title in English | Prognosis of Head and Neck Tumours in Relation to Tumour Suppressor p53 |
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| Authors | |
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | OTORINOLARYNGOLOGIE |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | tumour supressor p53 mutation; H-NSCC; prognosis |
| Description | Study objective: to find a correlation of tumor suppressor p53 mutation incidence in H&NSCC determined by immunohistological assay and FASAY (functional analysis of separated alleles in yeast) fucntional test with grading, staging, tumour localization and overall survival rate. Materials and methods: specimen of 50 patients with H&NSCC mostly resected during oncosurgery or obtained fromprobatory excision were included in the study. Gene p53was functionally analyzed by FASAY and mutation incidence by immunostaining with D07 Dakocymation monoclonal antibody. In accordance with other studies, we concluded that p53 prognostic value should be considered limiting. However, we pressume further research on biomarkers like gene p53 very promising. |
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