Clinical relevance of drug metabolism and metabolic interactions in psychopharmacotherapy

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Authors	HADAŠOVÁ Eva
Year of publication	2004
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	Psychotropics; metabolism; cytochromes P450; interactions
Description	Major factors of variability in the therapeutic response of psychotropics include genetic polymorphism of metabolizing enzymes (cytochromes P-450, transferases)and drug-drug interactions leading to the enzyme induction or inhibition.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems