Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy

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Authors

NOVÁKOVÁ Jana PISTOVČÁKOVÁ Jana VINKLEROVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2004
Type Article in Periodical
Magazine / Source Fundamental & Clinical Pharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords rats; 5-HT1 and 5-HT2 receptor ligands; methamphetamine; dependence; depression
Description The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders.
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