Influencing the epidermal growth factor receptor - new prospects in the treatment of non-small-cell bronchogenic carcinoma
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Studia Pneumologica et Phthiseologica |
| MU Faculty or unit | |
| Citation | |
| Field | Pneumology |
| Keywords | non-small-cell bronchogenic carcinomua; oncological therpy; epidermal growth factor receptor (EGFR); EGFR tyrosinekinase inhibitors; gefitinib |
| Description | To influence natural regulatory mechnisms, which control the metabolism, proliferation and migration of tumour cells, biological therapy resorts to low-molecular preparations, macromolecules and cellular immune-type effectors. Today we have primarily information on the influencing of the epidemal growth factor receptor - EGFR.Research concentrates above all on the possibility of inhibiting the intracellular domains of the EGF receptor that has a tyrosinekinase activity. This oncological tratment targes intracellular mechanism of the transfer ot the signal taht calls forth changes in the proliferation activity of tunour cells. In their paper the authors discuss various possibilities of influencing EGFR and their appliction in clinical practice. |
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